NanoBRET™ Intracellular CDK Panel for Target Engagement Screening

Accurately measure your compound’s CDK binding affinity and selectivity in the physiological environment of intact cells

Enroll before Aug 30 

NanoBRET assays are cutting-edge compound competition assays leveraging bioluminescence resonance energy transfer (BRET) between a luciferase-tagged kinase and a fluorescent tracer. This system ensures quantification and specificity, key attributes for accurate results.

Discover our NanoBRET™ Intracellular CDK Panel Screening

Reaction Biology NanoBRET™ Intracellular CDK Panel Screening service includes 20 clinically relevant CDK targets. This is an excellent platform for assessing your test compound’s binding affinity and selectivity across a diverse panel of CDK kinases in the physiological environment of intact cells, and it provides qualitative data on the test compound’s permeability, affinity, selectivity, and residence time.

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Why Choose Our Screening Service?

  • Comprehensive Analysis: Assess your compound across a diverse panel of clinically relevant CDK kinases.

  • High data quality: Conduct your screening in a 10-dose IC50 duplicate format.

  • Quick Turnaround: Receive your results in approximately 4 weeks.

  • High Reproducibility: Benefit from our semi-automated processing

  • Speedy Results: 2-3 weeks turnaround time. Expedited scheduling and data delivery options are available.

About NanoBRET assays

A NanoBRET assay allows you to:

  • Obtain real-time data on the binding affinity of your compound to a kinase target, including occupancy time

  • Understand your compound-kinase interaction inside an intact cell, in presence of physiological ion and ATP concentration, pH, or additional co-factors

  • Evaluate whether your compound is able to cross the cellular membrane to perform its function

  • Screen at high-throughput your compound library

 

Disclaimer: NanoBRET™ is a registered trademark of Promega Corporation. NanoBRET™ is used herein solely for descriptive purposes and to identify the use of this product in the provision of our services.  Reaction Biology is not affiliated with, endorsed by, or sponsored by Promega Corporation.

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