Why Choose HotSpot Kinase Screening?

Our HotSpot kinase screening service offers a precise and reliable picture of your compound’s kinase activity and selectivity on the largest human kinome panel using a proprietary radiometric filter binding assay optimized for maximal sensitivity.

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The industry's largest kinome panel

Choose from the industry’s largest human kinome panel, featuring up to 780+ kinases including specialized panels such as CDK, EGFR, and more.

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Detect true kinase activity 

HotSpot kinase screening uses the best-in-class filter binding radiometric assay  - the gold standard to evaluate kinase activity - that minimizes false positive and negatives.

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Test in physiologically relevant conditions 

Our validated radiometric assay is now available at physiologically relevant 1mM ATP concentrations.

Screen your compound with ATP-Max KinomeScreen, a full panel 340 wild type kinases, for comprehensive and deep interrogation.

Or choose ATP-Max Diversify, a tailored panel of representative isoforms from each major kinase family for quicker understanding.

Standard concentrations of  1μM, 10μM or apparent ATP-Km up to 100μM are also available for our full panel.

Quality Assurance

Receive a kinase-specific control compound in 10-dose IC50 format for every target we screen.

Flexibility

Suitable for both kinase inhibitors (including competitive, non-competitive, and allosteric inhibitors) and kinase activators.