Your Antibody-Drug Conjugate (ADC) Discovery Partner

End-to-end service offering from biochemical to in vivo testing

We are committed to ensuring that your molecule reaches its full potential for therapeutic efficacy and safety. Our in vitro and in vivo platforms offer solutions for each stage of your ADC discovery program.

Download our AACR 2024 ADC posters Contact Us

Antigen Binding Specificity and Potency
ADC molecules must demonstrate the same or similar antigen binding specificity and potency as the unconjugated antibody. We offer advanced solutions to meticulously evaluate and optimize antigen binding properties, ensuring maximum therapeutic benefit.

Perform high throughput selectivity / specificity testing using our protein microarrays
Determine binding potency using SPR, flow cytometry, and ELISA
Evaluate binding residential time (with on/off rate) for your antibody alone and after conjugation, using our state-of-the-art SPR capabilities
Characterize surface antigen expression (surfaceome) across 160 cancer cell lines with our OncoFlow-Profiler panel
Analyze receptor density by flow, using QIFIKIT

Internalization

Efficient internalization is crucial for the successful delivery of the payload to the target cells. We help assess the internalization kinetics of your ADC using flow cytometry or imaging, thus optimizing your compound for therapeutic efficacy.

Payload Cytotoxicity Profiling

Once internalized, the payload must exhibit the same or similar toxicological profile as the free payload without conjugation, ensuring safety and efficacy. Our solutions allow you to rigorously evaluate the cytotoxicity of your ADC payload, minimizing potential risks to your program.

Assess cancer cell proliferation after ADC and payload treatment using our large catalog of over 300 individual cancer cell lines
Leverage our ProLiFiler™ cancer cell panel screening service to evaluate your ADC and payload potency across more than 160 tumor types
Identify your ADC method of cell killing with our antibody dependent cellular cytotoxicity (ADCC) and complement dependent cytotoxicity (CDC) assays
Compare the activity of your ADC in 3D vs. 2D settings with our 3D ProLiFiler featuring 40 cancer spheroid lines.
Test for your ADC’s ability to induce DNA breaks

In Vivo Studies

In vivo studies provide critical insights into the pharmacokinetics, biodistribution, and efficacy of ADCs in living organisms. We offer broad capabilities to translate your early findings to physiologically relevant data with our advanced in vivo models.

Evaluate efficacy in vivo using our xenograft, syngeneic and humanized models. PK / PD readouts available as well.
Rapidly select your best ADC candidate and target tumor indication using our Hollow Fiber in vivo models engrafted with three different tumor cell lines simultaneously
Assess tolerability in vivo - both acute and chronic

Why Choose Reaction Biology?

Expertise. Our team comprises experienced scientists and researchers with a proven track record in ADC development.
From biochemical to in vivo studies under one roof. Choose from a diverse solution portfolio including biochemical, cell-based, and in vivo assays and a wide collection of well characterized cancer cell lines and in vivo models.
Customized Solutions. We understand that every project is unique, and we tailor our services to meet your specific requirements and goals.
Regulatory Compliance. Our GLP services adhere to stringent regulatory standards, ensuring compliance and reliability throughout the development process.

Your Antibody-Drug Conjugate (ADC) Discovery Partner

End-to-end service offering from biochemical to in vivo testing

We support every step of your ADC discovery program

Internalization

Payload Cytotoxicity Profiling

In Vivo Studies

GxP Potency Assays

Why Choose Reaction Biology?

Get Started Today

Unlock the full potential of your ADC development program with Reaction Biology

We support every step of your ADC discovery program

Internalization

Payload Cytotoxicity Profiling

In Vivo Studies

GxP Potency Assays

Why Choose Reaction Biology?

Get Started Today

Unlock the full potential of your ADC development program with Reaction Biology

Download our ADC AACR posters

Get Started Today